Browse entries in the PDBbind-CN Database

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Related entries of code: 2x2k
Entries with 90% protein sequence similarity cutoff in PDBbind
PDB CodeCheck DatabaseProtein Sequence Similarity
2ivuRCSB PDB    PDBbind314aa, >2IVU_1|Chain... *
2x2lRCSB PDB    PDBbind314aa, >2X2L_1|Chain... at 100%
2x2mRCSB PDB    PDBbind314aa, >2X2M_1|Chains... at 100%
4ckiRCSB PDB    PDBbind314aa, >4CKI_1|Chain... at 99%
4ckjRCSB PDB    PDBbind314aa, >4CKJ_1|Chain... at 100%
5amnRCSB PDB    PDBbind299aa, >5AMN_1|Chain... at 100%
Complexes with the same small molecule ligand
PDB CodeCheck DatabaseLigand Name
No complexes with the same small molecule ligand are found!
Entry Information
PDB ID2x2k
Complex TypeProtein-Ligand
PDBbind Subsetgeneral set
Protein NamePROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET
Ligand NameX2K
EC.Number E.C.2.7.10.1
Resolution 2.6(Å)
Affinity (Kd/Ki/IC50)IC50=0.30uM
Release Year2010
Protein/NA SequenceCheck fasta file
Primary Reference (2010) Bioorg.Med.Chem. Vol. 18: pp. 1482-1496
Ligand Properties
Formula C15H15N3O
Molecular Weight 253.299
Exact Mass 253.122
No. of atoms 34
No. of bonds 36
Polar Surface Area 70.91
LOGP Value 1.80      (Computed with XLOGP3)
3.43      (Computed with Open Babel)
Drug likeness No. of Hydrogen Bond Donors: 3
No. of Hydrogen Bond Acceptors: 1
No. of Rotatable Bonds: 1
No. of Nitrogen and Oxygen Atoms: 4
No. of Rings: 3
Canonical SMILES
InChI String

Links to External Databases
RCSB PDBThe mother database
PDBsumEnhanced annotations on PDB entries
PubchemComprehensive collection of chemical and biological data
UniProtKB ACUniProt accession number (AC): P07949  
Entrez Gene IDNCBI Entrez Gene ID: 5979  
ASDInformation of known allosteric effects of PDB entries
 
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