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Related entries of code: 3fzr
Entries with 90% protein sequence similarity cutoff in PDBbind
PDB CodeCheck DatabaseProtein Sequence Similarity
3et7RCSB PDB    PDBbind277aa, >3ET7_1|Chain... at 100%
3fzsRCSB PDB    PDBbind277aa, >3FZS_1|Chain... at 100%
3fztRCSB PDB    PDBbind277aa, >3FZT_1|Chain... at 100%
3h3cRCSB PDB    PDBbind277aa, >3H3C_1|Chain... at 100%
4h1jRCSB PDB    PDBbind293aa, >4H1J_1|Chain... *
4h1mRCSB PDB    PDBbind293aa, >4H1M_1|Chain... at 100%
5to8RCSB PDB    PDBbind282aa, >5TO8_1|Chain... at 98%
5tobRCSB PDB    PDBbind282aa, >5TOB_1|Chain... at 98%
Complexes with the same small molecule ligand
PDB CodeCheck DatabaseLigand Name
No complexes with the same small molecule ligand are found!

Entry Information
PDB ID3fzr
Complex TypeProtein-Ligand
PDBbind Subsetgeneral set
Protein NameProtein tyrosine kinase 2 beta
Ligand Name3JZ
EC.Number E.C.
Resolution 2.7(Å)
Affinity (Kd/Ki/IC50)IC50=11nM
Release Year2009
Protein/NA SequenceCheck fasta file
Primary Reference (2009) J.Biol.Chem. Vol. 284: pp. 13193-13201
Ligand Properties
Formula C22H21F3N6O3S
Molecular Weight 506.501
Exact Mass 506.135
No. of atoms 56
No. of bonds 59
Polar Surface Area 124.7
LOGP Value 2.77      (Computed with XLOGP3)
5.11      (Computed with Open Babel)
Drug likeness No. of Hydrogen Bond Donors: 3
No. of Hydrogen Bond Acceptors: 5
No. of Rotatable Bonds: 7
No. of Nitrogen and Oxygen Atoms: 9
No. of Rings: 4
Canonical SMILES
InChI String

Links to External Databases
RCSB PDBThe mother database
PDBsumEnhanced annotations on PDB entries
PubchemComprehensive collection of chemical and biological data
UniProtKB ACUniProt accession number (AC): Q14289  
Entrez Gene IDNCBI Entrez Gene ID: 2185  
ASDInformation of known allosteric effects of PDB entries

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