Browse entries in the PDBbind-CN Database

Display Options: Structure:  




Goto PDB code:

3D presentation of molecule is powered by 3Dmol, which supports all modern browsers and mobile devices via WebGL.

           
Hold mouse button: left to rotate,middle to shift,right to zoom

Related entries of code: 4rwk
Entries with 90% protein sequence similarity cutoff in PDBbind
PDB CodeCheck DatabaseProtein Sequence Similarity
1agwRCSB PDB    PDBbind310aa, >1AGW_1|Chains... at 99%
1fgiRCSB PDB    PDBbind310aa, >1FGI_1|Chains... at 99%
2fgiRCSB PDB    PDBbind310aa, >2FGI_1|Chains... at 99%
3c4fRCSB PDB    PDBbind302aa, >3C4F_1|Chains... at 99%
3rhxRCSB PDB    PDBbind306aa, >3RHX_1|Chains... at 99%
4f63RCSB PDB    PDBbind309aa, >4F63_1|Chains... at 99%
4f64RCSB PDB    PDBbind309aa, >4F64_1|Chains... at 99%
4f65RCSB PDB    PDBbind309aa, >4F65_1|Chains... at 99%
4nk9RCSB PDB    PDBbind309aa, >4NK9_1|Chains... at 99%
4nkaRCSB PDB    PDBbind309aa, >4NKA_1|Chains... at 99%
4nksRCSB PDB    PDBbind309aa, >4NKS_1|Chains... at 99%
4rwjRCSB PDB    PDBbind317aa, >4RWJ_1|Chains... at 96%
4rwlRCSB PDB    PDBbind317aa, >4RWL_1|Chains... at 96%
4v01RCSB PDB    PDBbind309aa, >4V01_1|Chains... at 99%
4v04RCSB PDB    PDBbind309aa, >4V04_1|Chains... at 99%
4v05RCSB PDB    PDBbind309aa, >4V05_1|Chains... at 99%
4zsaRCSB PDB    PDBbind308aa, >4ZSA_1|Chains... at 99%
5a46RCSB PDB    PDBbind386aa, >5A46_1|Chains... *
5a4cRCSB PDB    PDBbind307aa, >5A4C_1|Chains... at 99%
5am6RCSB PDB    PDBbind310aa, >5AM6_1|Chains... at 99%
5am7RCSB PDB    PDBbind310aa, >5AM7_1|Chains... at 98%
5ur1RCSB PDB    PDBbind311aa, >5UR1_1|Chains... at 98%
5vndRCSB PDB    PDBbind309aa, >5VND_1|Chains... at 98%
6nvlRCSB PDB    PDBbind309aa, >6NVL_1|Chains... at 99%
6mzwRCSB PDB    PDBbind311aa, >6MZW_1|Chains... at 98%
6mzqRCSB PDB    PDBbind311aa, >6MZQ_1|Chains... at 98%
6itjRCSB PDB    PDBbind308aa, >6ITJ_1|Chains... at 99%
Complexes with the same small molecule ligand
PDB CodeCheck DatabaseLigand Name
4rwjRCSB PDB    PDBbind66T
4v05RCSB PDB    PDBbind66T

Entry Information
PDB ID4rwk
Complex TypeProtein-Ligand
PDBbind Subsetgeneral set
Protein NameV561M FGFR1 gatekeeper mutation (C488A, C584S, V561M)
Ligand Name66T
EC.Number E.C.2.7.10.1
Resolution 2.98(Å)
Affinity (Kd/Ki/IC50)Kd=64nM
Release Year2015
Protein/NA SequenceCheck fasta file
Primary Reference (2015) Acs Chem.Biol. Vol. 10: pp. 1319-1329
Ligand Properties
Formula C26H34N5O3
Molecular Weight 464.580
Exact Mass 464.266
No. of atoms 68
No. of bonds 71
Polar Surface Area 96.09
LOGP Value 3.91      (Computed with XLOGP3)
4.33      (Computed with Open Babel)
Drug likeness No. of Hydrogen Bond Donors: 3
No. of Hydrogen Bond Acceptors: 2
No. of Rotatable Bonds: 9
No. of Nitrogen and Oxygen Atoms: 8
No. of Rings: 4
Canonical SMILES
InChI String

Links to External Databases
RCSB PDBThe mother database
PDBsumEnhanced annotations on PDB entries
PubchemComprehensive collection of chemical and biological data
UniProtKB ACUniProt accession number (AC): P11362  
Entrez Gene IDNCBI Entrez Gene ID: 2260  
ASDInformation of known allosteric effects of PDB entries

 
This site has been visited times since Nov 2007.


Copyright ©2007-2024    涓婃捣鐩堣禌鎬濅俊鎭鎶鏈夐檺鍏徃    缃戠珯澶囨鍙凤細娌狪CP澶2021015625鍙-3    娌叕缃戝畨澶囷細姝e湪鐢宠涓


Technical Support锛堟妧鏈敮鎸侊級: yingsaisi@foxmail.com