Browse entries in the PDBbind-CN Database

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Related entries of code: 6mwe
Entries with 90% protein sequence similarity cutoff in PDBbind
PDB CodeCheck DatabaseProtein Sequence Similarity
2oo8RCSB PDB    PDBbind317aa, >2OO8_1|Chain... at 99%
2oscRCSB PDB    PDBbind317aa, >2OSC_1|Chain... at 99%
2p4iRCSB PDB    PDBbind317aa, >2P4I_1|Chains... at 99%
2wqbRCSB PDB    PDBbind324aa, >2WQB_1|Chain... *
Complexes with the same small molecule ligand
PDB CodeCheck DatabaseLigand Name
3qriRCSB PDB    PDBbind919
3qrjRCSB PDB    PDBbind919

Entry Information
PDB ID6mwe
Complex TypeProtein-Ligand
PDBbind Subsetgeneral set
Protein NameTie2 kinase
Ligand Name919
EC.Number E.C.-.-.-.-
Resolution 2.05(Å)
Affinity (Kd/Ki/IC50)Kd=0.63nM
Release Year2018
Protein/NA SequenceCheck fasta file
Primary Reference (2017) Mol. Cancer Ther. Vol. 16: pp. 2486-2501
Ligand Properties
Formula C30H28FN7O3
Molecular Weight 553.587
Exact Mass 553.224
No. of atoms 69
No. of bonds 73
Polar Surface Area 123.06
LOGP Value 4.93      (Computed with XLOGP3)
6.58      (Computed with Open Babel)
Drug likeness No. of Hydrogen Bond Donors: 3
No. of Hydrogen Bond Acceptors: 5
No. of Rotatable Bonds: 10
No. of Nitrogen and Oxygen Atoms: 10
No. of Rings: 5
Canonical SMILES
InChI String

Links to External Databases
RCSB PDBThe mother database
PDBsumEnhanced annotations on PDB entries
PubchemComprehensive collection of chemical and biological data
UniProtKB ACUniProt accession number (AC): Q02763  
Entrez Gene IDNCBI Entrez Gene ID: 7010  
ASDInformation of known allosteric effects of PDB entries

 
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